With the latest (1.9.10) version of Serato, you can use the Denon DJ SC5000 in Serato Controller Mode: See more here: -
Please note: It is possible to use the Prime/Serato Controller Mode in (up to) a 3-player set-up, without the need for an external powered USB hub – by using one SC5000 as a ‘powered USB hub’ and daisy-chaining. Please follow these connections guidelines and note the highlight on use of a USB 3.0 Cable - Daisy chaining setup examples below:
2 DECKS (SC5000 1 used as powered hub)
SC5000 1 to PC/Mac via USB 3.0 Cable X1800 to PC/Mac via USB 2.0 Cable SC5000 2 to SC5000 1 USB 2/3 via USB 3.0 Cable
3 DECKS (SC5000 1 used as powered hub)
SC5000 1 to PC/Mac via USB 3.0 Cable X1800 to PC/Mac via USB 2.0 Cable SC5000 2 to SC5000 1 USB 2 via USB 3.0 Cable SC5000 3 to SC5000 1 USB 3 via USB 3.0 Cable
4 DECKS (Use an external powered hub to minimize the number of hubs used)
Powered USB 3.0 hub to PC/Mac via USB 3.0 Cable SC5000 1 to Hub via USB 3.0 Cable X1800 to PC/Mac via USB 2.0 Cable SC5000 2 hub via USB 3.0 Cable SC5000 3 hub via USB 3.0 Cable SC5000 4 hub via USB 3.0 Cable